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According to Collins English dictionary, drug delivery
system is a system that is used as a medium or carrier for administering a
pharmaceutical product to patient (1) which consist of a formula of therapeutic
substance and control time, rate and destination of the released drugs in the
body to enable and improve the efficacy and safety of the medicine. To develop
a new substance of drug is considered expensive and took a lot of time. So many
researcher had attempt to study and developed the existing methode of delivery
such as sustain released and delayed release. The term pharmaceutical material also
applies to an agent such as gene therapy that will induce in vivo production of
the active therapeutic compound. Gene therapy can fit in the basic and broad
definition of a drug delivery system. Gene vectors may need to be introduced
into the human body by new delivery methods. Drug can be delivered through many
ways e.g. through mouth, skin (topical), and inhalation routes etc. It may
include a target area in the body concerned with quantity and duration of drug
presence. As rate and amount of dosage in the body
must be well calculated so in the traditional drug delivery methods where dose
rate is calculated and delivered manually any type of mishandling can lead to
certain complications in a patient. This distinction between the drug and the
device is important, as it is the criterion for regulatory control of the
delivery system by the drug control agency. Many investigation on human and animal have results
the increased understanding on the principles of pharmacokinetics and
pharmacodynamics and influence the hypnotic, sedatrive and analgesic action and
tendency. The research proves that there are another option for anesthetic and
analgesic drug route such as via buccal, skin, and nasal mucus. This stimulate
the interest of pharmaceutical company to invest more research and development
find the new method of drug delivery system instead of looking for new pharmaceutical
substance. Because the cost of finding of new pharmaceutical substance from the
research, develop, do the clinical test and for regulatory approval from
government in the US is about $120 million and spent more than a decade. But
for a development of improved drug delivery system cost roughly 40% of marketed
drugs at the US in 2000(2-4)

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